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Sunday, 16 October 2011

10.30 - 12.00 Author Workshop
13.00 - 15.00 Session 1 - DNA Repair Machines
Session Chair: Tom Blundell
13.00 - 13.05 Welcome by Elsevier
13.05 - 13.15 Introduction by Conference Chairs: Tom Blundell and John Tainer
13.15 - 13.50 [K01] Setting the scene: DNA repair complexes and a dawn for structural and mechanistic systems biology
John Tainer, The Scripps Research Institute, USA
13.50 - 14.25 [K02] Molecular machines of double-strand break repair: What they look like and how they work
Claire Wyman, Erasmus Medical Center, The Netherlands
14.25 - 15.00 [K03] Structural architecture and remodeling of modular multi-domain proteins in DNA repair machines
Walter Chazin, Vanderbilt University, USA
15.00 - 15.30 Refreshment Break
15.30 - 17.40 Session 2 - Chromatin & Damage Responses
Session Chair: Laurence Pearl
15.30 - 16.05 [K04] The role of the RSC chromatin remodelling complex in DNA damage responses
Jessica Downs, University of Sussex, UK
16.05 - 16.40 [K05] Structure and mechanism of the INO80 complex
Dale Wigley, The Institute of Cancer Research, UK
16.40 - 17.00 [O2.1] Chromatin dynamics revealed by time-lapse AFM
Y. Lyubchenko*, L. Shlyakhtenko, A. Miyagi; University of Nebraska Medical Center, USA
17.00 - 17.20 [O2.2] Lesion-induced pairing of sister chromatids enables homologous repair of double-strand DNA breaks in bacteria
N. Shechter, A. Weiner, A. Minsky*; The Weizmann Institute of Science, Israel
17.20 - 17.40 [O2.3] Structure of TDG bound to substrate analogue informs its catalytic mechanism and its weak G•T repair activity
A. Maiti, E. Pozharski, A.C. Drohat*; University of Maryland School of Medicine, USA
18.00 - 19.30 Welcome reception and poster session 1

Monday, 17 October 2011

8.30 - 10.40 Session 3 - DNA Remodeling & Fidelity
Session Chair: Jessica Downs
8.30 - 9.05 [K06] Recognition and repair of DNA single-strand breaks
Laurence Pearl, University of Sussex, UK
9.05 - 9.40 [K07] Towards damage verification in nucleotide excision repair
Caroline Kisker, University of Würzburg- Rudolf Virchow Center, Germany
9.40 - 10.00 [O3.1] The UvrA•UvrB DNA damage sensor: Structure and mechanism
D. Jeruzalmi*, D. Pakotiprapha, M. Samuels, K. Shen, J. Hu; Harvard University, USA
10.00 - 10.20 [O3.2] Structure of REV7 in complex with a REV3 fragment and structural implication of the interaction between DNA polymerase ζ and REV1
H. Hashimoto*¹, K. Hara, Y. Murakumo², S. Kobayashi³, S. Takeda³, M. Sato¹; ¹Yokohama City University, Japan, ²Nagoya University, Japan, ³Kyoto University, Japan
10.20 - 10.40 [O3.3] Characterization of the structure and dynamics of hMutSα- and hMutSα-hMutLα-heteroduplex complexes using AFM and single molecule fluorescence
D. Burke¹, V. DeRocco¹, B. Wang¹, C. Du², P. Hsieh², D.A. Erie*¹; ¹University of North Carolina, USA, ²NIDDK, NIH, USA
10.40 - 11.10 Refreshment Break
11.10 - 13.00 Session 4 - Replication & Mismatch Repair
Session Chair: Wei Yang
11.10 - 11.45 [K08] Molecular insights into the function of proteins important for DNA replication and repair
Luca Pellegrini, University of Cambridge UK
11.45 - 12.20 [K09] Molecular insight into polymerase fidelity
Lars C. Pedersen, NIH,USA
12.20 - 12.55 [K10] Genesis and repair of DNA replication errors
Lorena Beese, Duke University, USA
13.00 - 14.30 Lunch + Meet the Professors
Walter Chazin, Loreena Beese, Luca Pellegrini, Caroline Kiser and Jessica Downs
14.30 - 16.00 Poster Session 2 + refreshments
16.00 - 17.40 Session 5 - Repair Mechanisms & Disease
Session: Oscar Llorca
15.30 - 16.05 [K11] Conformational dynamics of the Mre11-Rad50-Nbs1 complex in DNA double-strand break repair
Karl-Peter Hopfner, Ludwig-Maximilians-University Munich, Germany
16.05 - 16.40 [K12] DNA repair enzymes: Structure, chemistry and disease
Wei Yang, NIH,USA
16.40 - 17.00 [O5.1] DNA replication and repair enzymes as targets for antibacterial drug discovery
G. Sanyal, AstraZeneca R&D Boston, USA
17.00 - 17.20 [O5.2] Defining key molecular mechanisms of the sumoylation pathway functioning to regulate DNA repair
J.J.P. Perry*, J. Prudden, A.S. Arvai, C. Hitomi, J.A. Tainer, M.N. Boddy; The Scripps Research Institute, USA
17.20 - 17.40 [O5.3] Self-catalyzed site-specific DNA depurination and the origin of mutations in disease-related genes
J.R. Fresco*, O. Amosova; Princeton University, USA
19.00 - 22.00 Conference dinner

Tuesday, 18 October 2011

8.30 - 10.40 Session 6 - Processing Breaks and Forks
Session Chair: Luca Pellegrini
8.30 - 9.05 [K13] Structural Biology of Double-Strand Breaks Repair in both Non-Homologous End Joining and Homologous Recombination Pathways
Tom Blundell, University of Cambridge, UK
9.05 - 9.40 [K14] DNA double strand break repair: Assembly of a functional repair complex
Murray Junop, McMaster University, Canada
9.40 - 10.00 [O6.1] Structural characterization of the filaments formed by the Xrcc4-Cernunnos/XLF complex by crystallography and electron microscopy
J.B. Charbonnier*¹,², V. Ropars¹,², P. Drevet¹,², P. Legrand³, S. Baconnais², J. Amram¹,², et al; ¹CEA, France, ²CNRS, France, ³Synchrotron SOLEIL, France
10.00 - 10.20 [O6.2] Molecular architecture and switching mechanism of DNA replication fork complex as revealed by single particle analysis
K. Mayanagi, Kyushu University, Japan
10.20 - 10.40 [O6.3] Structural basis of aprataxin DNA ligase proofreading with insights into AOA1 neurodegenerative disease
R.S. Williams, NIH/NIEHS, USA
10.40 - 11.10 Refreshment Break
11.10 - 13.00 Session 7 - Healing Ends
Session Chair: Stephen Smerdon
11.10 - 11.45 [K15] Mechanisms of 5’ and 3’ DNA recognition by the DNA repair enzyme, polynucleotide kinase/phosphatase
Mark Glover, University of Alberta, Canada
11.45 - 12.20 [K16] Many ways to make ends meet: Polymerase-mediated orchestration of DNA double-strand break repair
Aidan Doherty, University of Sussex, UK
12.20 - 12.55 [K17] Structural chemical biology of DNA end joining
Tom Ellenberger, Washington University School of Medicine, USA
13.00 - 13.30 Sofa Session: Pathway interactions & possible chemical controls
13.00 - 14.30 Poster Session 3 + Lunch
14.30 - 16.00 Session 8 - Damage Signaling
Session Chair: Claire Wyman
14.30 - 14.40 Poster Award Ceremony
14.40 - 15.15 [K18] Scaffolds and adaptors in DNA-damage response signalling
Stephen Smerdon, MRC National Institute for Medical Research, UK
15.15 - 15.50 [K19] Molecular architecture and regulation of the large PI3K-like protein kinases (PIKKs)
Oscar Llorca, Spanish National Research Council, Spain
15.50 - 16.00 Closing Remarks
Tom Blundell